Additionally, unphosphorylated SAMHD1 plays a crucial role in maintaining a low intracellular dNTP levels in quiescent cells, including macrophages and quiescent CD4 + T cells, where it mediates viral restriction.1,7,52,53 Altered dNTP levels could result in DNA damage and aberrant replication, potentially leading to tumorigenesis.57 SAMHD1 also has key roles in innate immune regulation and DNA damage responses.22 Therefore, it is important to preserve SAMHD1 function in normal resting cells when selectively targeting SAMHD1 in tumor cells. The gene discussed is CD4; the disease is neoplasm.