SAMHD1 has been shown to influence viral replication.24,37 Factors interacting with SAMHD1 such as DDB1 and hnRNP A1, have been linked to viral infection including HIV-11,6,38 and SARS-COV-2.39 We first confirmed the interaction between SAMHD1 and HSP90 in HEK293T cells by co-IP and western blot analysis (Supplementary Fig. 2a). The gene discussed is DDB1; the disease is viral infectious disease.