In myeloid cells and resting CD4 + T lymphocytes, SAMHD1 helps maintain low dNTPs levels, limiting viral DNA synthesis and restricting the infection of a variety of viruses, including HIV.1,5–8 Beyond its enzymatic dNTPase activity, SAMHD1 also exerts a dNTPase-independent viral restriction function,9–12 which further underscores its broad antiviral capabilities. Here, SAMHD1 is linked to infection.