MRE11 and neoplasm: It has been reported that the p-SAMHD1 recruit meiotic recombination 11 (MRE11) to remove intracellular DNA fragments, thereby preventing activation of the cGAS-STING pathway.22 Activation of the cGAS-STING pathway leads to the production of type-I interferons and other inflammatory cytokines, which can enhance anti-tumor immune responses.