IL6 and obesity due to melanocortin 4 receptor deficiency: Mardinoglu et al. demonstrated that the reduced TNF-α and IL-6 after a two-week isocaloric ketogenic diet was associated with increased folate production by the gut microbiota, due to more growth of the folate-producing Streptococcus and Lactococcus [80] in ten patients with obesity and MASLD .