Consistent with improved blood BUN levels (Fig. 3c), Nutlin 3b relieved hyalination, a sign of renal sclerosis, SASP (Tnfα, Cxcl1, Ccl5) and the senescent marker p16Ink4a in aged kidneys (Fig. 6e and Supplementary Fig. 15c). Here, CXCL1 is linked to nephrosclerosis.