These findings indicate that the biological role of DCN in this context may differ from previously shown tumour‐suppressive functions through interaction with several receptor tyrosine kinases, including EGFR, Met, and IGF‐IR [38, 39, 40], and by attenuating the effect of TGF‐beta [41], a potent modulator in the tumour microenvironment. This evidence concerns the gene NTRK1 and neoplasm.