FGF21 and cancer: These include bsAbs as factor VIII-mimetics with hemostatic or cofactor activities (78, 79), FGF21-mimetics with metabolic activities (80, 81), IL-2-mimetics that promote expansion of lymphocytes (82, 83), a type-I IFN-mimetic with antiviral ability (83), an EPO-mimetic to regulate red blood cell production (84), and an IL-18-mimetic for cancer therapy (85).