The role of Plin4 in MASLD can therefore be interpreted differently; lack of Plin4 may be seen as protective by reducing hepatic TAG levels or alternatively, Plin4 may be seen as not protective given that the expression of inflammatory and fibrotic markers is unaffected, despite reduced TAG levels and signs of reduced ER stress. Here, PLIN4 is linked to metabolic dysfunction-associated steatotic liver disease.