Overexpression of SIRT3 significantly enhanced the cytotoxicity of MRTX1133 against pancreatic cancer cells (PANC1) in a colony formation assay (Fig. S7A), whereas SIRT3 knockdown by shRNA reduced the sensitivity of PANC1 cells to MRTX1133 treatment (Fig. S7B). The gene discussed is SIRT3; the disease is pancreatic neoplasm.