CFB and systemic lupus erythematosus: ,31 The genetic overlap between VVs and autoimmune diseases such as systemic lupus erythematosus (rs17321999 [intron variant of LBH], rs4849044 [intron variant of FBLN7], rs7773004 [intergenic variant of H2BC9], and rs61863928 [regulatory region variant of ALDH7A1P4]) and rheumatoid arthritis (rs4151657 [intron variant of CFB]) have also been studied, providing insight into the underlying shared mechanisms of pathogenesis such as dysregulated immunity with other diseases.22