Findings from our previous studies revealed that islet‐derived inflammation disseminates via proinflammatory macrophages and extracellular vesicles (EVs) enriched with miR‐29 and miR‐503 to insulin‐responsive tissues (liver, skeletal muscle, adipose tissue), which establishes a feed‐forward cycle of peripheral inflammation and insulin resistance—a critical pathway in geriatric T2DM pathogenesis (Sun et al. 2021; Zhou et al. 2024). This evidence concerns the gene INS and type 2 diabetes mellitus.