Compared with patients who remain positive for aPL, patients who became aPL-negative had a similar proportion of recurrent thrombosis before aPL-negativization (43.0% vs 27.0%, P = 0.098), and a significant decrease in the proportion of recurrent thrombosis after aPL-negativization (43.0% vs 8.1%, P <0.001). This evidence concerns the gene FASLG and Venous thrombosis.