Among ICI patients, 97% were male, 70% were non‐Hispanic White, 81% were between 60 and 79 years old, 62% had adenocarcinoma tumor histology, 30% had tumor PD‐L1 expression 50%–100%, 45% received ICI in combination with chemotherapy, and 71% were treated in the first line. Here, CD274 is linked to adenocarcinoma.