In the absence of AOM/DSS, long-term (4 months) ALKBH5 knockout (Fig. S3A, B) had no effect on intestinal homeostasis, as evidenced by histological analysis of small intestine and colon (Fig. S3C), and measurement of colon length and body weight (Fig. S3D). The gene discussed is ALKBH5; the disease is infectious otitis media.