LGR5 and colorectal carcinoma: In a second cohort (N = 12), ALKBH5 protein was up-regulated in CRC (Fig. S1H and S1I), and positively correlated with CD133 (P = 0.0002, R = 0.721) and LGR5 (P < 0.0001, R = 0.797) (Fig. S1J).