APOE and Alzheimer disease: The non-APOE shared genetic risk score demonstrated a significant association with the combined AD or LOE phenotype (OR = 1.24, 95% CI: 1.06, 1.45) and LOE-only (OR = 1.21, 95% CI: 1.01, 1.46), and a borderline associations with AD-only (OR = 1.28, 95% CI: 0.99, 1.66).