APOE and Alzheimer disease: After accounting for age at last visit, sex, and ancestry-specific genetic variations (represented by principal components (PCs)), APOE-ε4 was significantly associated with AD (OR = 2.85, 95% CI: 2.34, 3.48) and showed a borderline association with LOE (OR = 1.20, 95% CI: 0.99, 1.45), suggesting a modest shared genetic contribution.