APOE and Alzheimer disease: Further examination of the effect sizes of these genetic factors (Supplementary Table 2) revealed that only APOE-ε4 allele count was significantly associated with an increased risk of AD when adjusting for LOE status (Cox model: HR = 2.53, 95% CI: 2.10, 3.05; Fine and Gray model: HR = 2.51, 95% CI: 2.07, 3.05).