In contrast, ORAI1 depletion had no significant effect on ALDH1B1 expression in confined tumor cells (Supplementary Fig. 6i, j), while TRPV4 depletion partially abrogated ALDH1B1 upregulation (Supplementary Fig. 6k, l), though unlike PIEZO1 depletion, which completely abrogated ALDH1B1 upregulation in confined tumor cells. This evidence concerns the gene TRPV4 and neoplasm.