Similarly, overexpression of ALDH1B1 decreased lipid peroxidation levels and restored the survival and migration of CSK23-depleted cells in confining spaces (Fig. 6h–j and Supplementary Fig. 10l–s), whereas CSK23 depletion showed no significant impact on lipid peroxidation or survival in unconfined tumor cells (Fig. 6h, i and Supplementary Fig. 10d–h and 10o–q). This evidence concerns the gene ALDH1B1 and neoplasm.