Importantly, we depleted IKKβ in tumor cells (Supplementary Fig. 8e, f) and observed that depletion of IKKβ suppressed the compression-induced phosphorylation and degradation of IκBα as well as ALDH1B1 expression (Fig. 5e–g and Supplementary Fig. 8g–i). The gene discussed is ALDH1B1; the disease is neoplasm.