TP53 and colorectal carcinoma: They were RTK-RAS (effect size = 0.71 and FDR = 0.001) and TGF-Beta (effect size = 0.73 and FDR = 0.010) in CRC MSS, TP53 in LUAD (effect size = 0.6 and FDR = 0.002), PRAD (effect size = 0.5 and FDR = 0.004), UCEC ENDO (effect size = 0.47 and FDR = 0.034), Hippo in UCEC HM (effect size = 2.78 and FDR = 0.022) (Fig. 5a).