ESR1 and cancer: Comprehensive OR analysis with multivariable logistic regression analysis, adjusted with cancer subtype, gene panel et al. (see method), of PM versus non-PM revealed significantly enriched mutations in ESR1 [OR(95%CI) = 1.70(1.45–1.98), FDR = 0.01], TCF7L2 [OR(95%CI) = 0.60(0.52–0.69), FDR = 0.006], FBXW7[OR(95CI) = 0.72(0.65–0.80), FDR = 0.03] (Fig. 3b; Supplementary Data 4).