elegans, exogenous LCA acts as a DR-mimetic and extends lifespan by activating the conserved AAK-2/AMPK-SIR-2.1/SIRT1 axis through TUB-1/TUB-like protein 3 (TULP3)-dependent signaling (Qu et al., 2025a, Qu et al., 2025b). The gene discussed is TULP3; the disease is Leber congenital amaurosis.