Finally, the repressed genes in Rpl22−/− leukemias are similarly implicated in leukemia pathogenesis including Asxl2, Cdkn2a, and Hpse2, which have been found to be frequently mutated in leukemias (Figues 7A and S6B).64–67 Among the diverse differentially regulated genes in Rpl22−/− leukemias, 10% are linked to metabolism, with fatty acid metabolism being the most enriched, upregulated metabolic pathway (Figures 7C, 7D, and S6C–S6E). This evidence concerns the gene HPSE2 and leukemia.