RPL22 and leukemia: In addition, our contention that increased triglyceride synthesis is important in supporting the survival of Rpl22-deficient leukemias is based on pharmacologic inhibition, which attenuates the survival of Rpl22-deficient leukemias in vitro; however, because pharmacologic agents have off-target effects, it remains possible that attenuation of a potential off-target activity also plays a role in the preferential impairment of Rpl22-deficient leukemias.