The reduction in oxygen consumption is likely to result from reduced expression of ATP5e, which is important for the consumption of oxygen by ETC complex IV.46 This is consistent with our observation that Atp5e expression is no longer reduced in the Rpl22−/− leukemias, which exhibit OCR levels equivalent to their Rpl22+/+ counterparts (data not shown). The gene discussed is SPIN1; the disease is leukemia.