SIX1 and leukemia: Prtn3 and Laptm4b are reported to promote leukemogenesis by regulating STAT3 signaling, while Dock1 is a guanine nucleotide exchange factor thought to promote leukemogenesis through Notch activation.56–59 Key transcriptional regulators are also induced in Rpl22−/− leukemias including Mansc1 (MN1), which serves as a critical transcriptional co-factor in MLL-rearranged leukemias, and Six1, which promotes leukemia by regulating the expression of glycolytic genes (Figure 7A)60,61.