Importantly, of the 1,219 genes upregulated in Rpl22-deficient leukemias, nearly 10% (102) are either direct Lin28b targets or indirect targets regulated through Lin28b effects on Let-7 micro-RNAs (mIRs) (Figure 7F; Table S4).76,77 These targets include many that are required for leukemia survival, such as Myc, Rps13, and CDK6 (Figure S7A) as well as those implicated in lipid metabolism (Figure S7B). The gene discussed is MYC; the disease is leukemia.