We have previously shown that Lin28b upregulation is critical for the pathogenesis of Rpl22− thymic lymphomas driven by transgenic expression of myristoylated-Akt2, and in this case Lin28b induction was dependent on nuclear factor (NF)-κB.22 NF-κB does not appear to be responsible for Lin28b induction in the Rpl22-deficient myeloid leukemia cells since the RNA-seq analysis did not identify an NF-κB signature. Here, RPL22 is linked to thymus lymphoma.