RPL22 and leukemia: Finally, inhibition of acyl-coenzyme A (CoA):diacylglycerol acyltransferase 1 (DAGAT1),78 a critical enzyme in TG synthesis,79 resulted in preferential attenuation of the survival of Rpl22−/− leukemias (Figure 7I), indicating that Lin28b-mediated promotion of lipid synthesis is critical for pathogenesis of Rpl22−/− leukemias.