KMT2A and leukemia: To gain insight into the molecular basis for the control of lipid metabolism by Rpl22 and to make a broader assessment of the regulation of leukemogenesis by Rpl22, we performed RNA sequencing (RNA-seq) on Rpl22+/+ and Rpl22−/− leukemias that developed in the MLL-AF9 transgenic mice (Figures 7A and S6A).