CDK6 and leukemia: Importantly, of the 1,219 genes upregulated in Rpl22-deficient leukemias, nearly 10% (102) are either direct Lin28b targets or indirect targets regulated through Lin28b effects on Let-7 micro-RNAs (mIRs) (Figure 7F; Table S4).76,77 These targets include many that are required for leukemia survival, such as Myc, Rps13, and CDK6 (Figure S7A) as well as those implicated in lipid metabolism (Figure S7B).