TRPV4 and atherosclerosis: Matrix stiffening is a hallmark of atherosclerosis and other fibrotic diseases [23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 59, 60, 61], and the role of TRPV4 as a stiffness sensor positions it as a critical mediator of pathological remodeling in these conditions.