While the quartile‐based HV cut‐off used here clearly enriches in the proportion of individuals with concomitant LATE, it does not definitively distinguish the presence of TDP‐43 co‐pathology from other potential drivers of hippocampal atrophy, for example, non‐AD pathologies, such as argyrophilic grain disease (AGD), frontotemporal lobar degeneration (FTLD), including other TDP‐43 pathologies, and cerebrovascular disease. The gene discussed is TARDBP; the disease is cerebrovascular disorder.