To further investigate the impact of HDAC1 dysregulation on neuroinflammation and oxidative stress following stroke, we analysed the levels of key inflammatory cytokines (IL-1β, IL-6, and TNF-α), matrix metalloproteinases (MMPs) activity, lactate dehydrogenase (LDH), and reactive oxygen species (ROS) production in the brain tissue of Sham, Stroke, and Stroke + HDAC1 KD groups 3 days after stroke. This evidence concerns the gene IL1B and stroke disorder.