In the T2D model, TH mice exhibited more severe hyperglycemia, insulin resistance, and β‐cell dysfunction than TN mice, accompanied by increased hepatic TNF‐α and IL‐6 expression, enhanced lipid accumulation, suppressed IRS‐1 phosphorylation, and enhanced JNK and IKKβ phosphorylation. The gene discussed is TNF; the disease is type 2 diabetes mellitus.