CD8A and Alzheimer disease: In CSF of AD patients, clonally expanded and antigen‐specific CD8+ T cells were detected [79], and flow cytometry and immunohistochemistry in APP‐PS1 mice revealed CD8+ TRM, with GO enrichment and KEGG pathway analysis showing that genes related to the type I IFN signaling pathway, such as Ifnar2 and Irf9, were upregulated [78].