These engineered CAR-Ms selectively engulfed NKG2DL-positive tumor cells through FcγRI-mediated phagocytosis while simultaneously secreting pro-inflammatory cytokines (e.g., TNF-α, IL-12), a dual functional output driven by coordinated activation of the PI3K-AKT and cGAS-STING signaling pathways. Here, STING1 is linked to neoplasm.