Tumor co-culture induced further enhancement of M1-associated markers including CD80/CD86, MHC-II and IL-1β/IL-6/TNF-α/IL-12/IFN-γ, while suppressing M2 markers CD163/CD206 (Fig. 2B-E), indicating tumor-triggered M1 polarization. The gene discussed is IL1B; the disease is neoplasm.