Noteworthy, the response obtained in AD astrocytes was in the same direction but much more increased, showing increased expression in hundreds and even thousands of times in comparison with unstimulated conditions (IL1b: 1151-fold increase, p < 0.05; IL-6: 616-fold increase, p = 0.06; IL-8: 805-fold increase, p < 0.05; IL-23 A: 28-fold increase, p < 0.05; CCL-2: 8.7-fold increase, p < 0.05; CCL5: 3337-fold increase, p < 0.05; TNF-a: 180-fold increase, p < 0.05), showing notable and significant higher levels of pro-inflammatory cytokines after TIC incubation in comparison with CTRL astrocytes. The gene discussed is TNF; the disease is Alzheimer disease.