MFN2 and Alzheimer disease: The expression of Ser616-phosphorylated Drp1 (dynamin-related protein 1) protein (involved in mitochondrial fission) was significantly diminished in AD astrocytes (50% reduction, p < 0.05) but, on the contrary, the expression of the Mitofusin 2 (MFN2, involved in mitochondrial fusion) protein was increased in this group of astrocytes (50% of increase, p < 0.05).