These include the Martin/Hopkins Eqs [6–8]., the Sampson Eq [9]., and the more recent Modified Sampson Method, which is designed to enhance accuracy, particularly in samples with moderate to severe hypertriglyceridemia [10].Additional markers, such as non-HDL-C and apoB, are increasingly used for more precise risk assessment, especially in patients with metabolic disturbances [3, 5]. This evidence concerns the gene APOB and hypertriglyceridemia.