For example, palbociclib in combination with mTOR inhibitors (i.e. rapamycin and everolimus) or the dual mTOR/phosphatidylinositol 3-kinase (PI3K) inhibitor PF04691502 enhanced senescence in bothin vitro and in vivonon-small cell lung cancer models [47]. The gene discussed is MTOR; the disease is small cell lung carcinoma.