NFKB1 and hepatocellular carcinoma: Moreover, studies on the lung pre-metastatic niche in liver cancer have shown that exosomes derived from hepatocellular carcinoma contain miR-1247-3p, which drives metastasis by converting fibroblasts into CAFs through the downregulation of β−1,4-galactosyltransferase, thereby activating the β1-integrin-NF-κB signaling pathway [146].