We observed a significant correlation between IL-6 and JAK-STAT signaling pathways with complement and coagulation pathways, metabolic signatures and PD-1 signaling in the LC group (Fig. 2d), suggesting a potentially coordinated role of these pathways in the pathogenesis of LC, while the IL-6 and JAK-STAT signaling pathways correlated negatively with the metabolism of amino acids and oxidative stress in the LC group (Fig. 2d). Here, PDCD1 is linked to laryngotracheoesophageal cleft.