IL6 and infection: Transcriptomic analysis of peripheral blood in the LC (n = 10) and CC (n = 12) groups at day 90–180 after infection indicated upregulation of pathways linked to proinflammatory cytokine signaling (IL-6, IL-10 and IL-12 signaling), complement activation, proinflammatory immune cell signaling, signatures of T cell exhaustion and certain metabolic and immune regulation pathways in the LC compared with the CC group (Fig. 5b).