Pathways associated with IL-6, JAK-STAT and JAK1 signaling were upregulated at both day 90–180 (Fig. 3a) and more than 180 days (Fig. 3b) in the LC group compared to the CC group, as highlighted by the persistent increase of several leading genes in the pathways, including IL6R, IL6, IL1R, CD14, CSF1, CSF3RLEPR, IL4R, STAT1, STAT3 and JAK2 (Fig. 3a,b). The gene discussed is SOAT1; the disease is laryngotracheoesophageal cleft.