Weighted gene correlation network analysis revealed that individual markers of the JAK-STAT and IL-6 signaling pathways, including IL6R, AKT1, JAK2, IL1B, IFNGR1 and IFNGR2 and CD14 were highly correlated and positively associated with the subsequent development of LC (Fig. 3c). Here, IFNGR2 is linked to laryngotracheoesophageal cleft.