IL1B and laryngotracheoesophageal cleft: Weighted gene correlation network analysis revealed that individual markers of the JAK-STAT and IL-6 signaling pathways, including IL6R, AKT1, JAK2, IL1B, IFNGR1 and IFNGR2 and CD14 were highly correlated and positively associated with the subsequent development of LC (Fig. 3c).