BCL2 and hepatocellular carcinoma: Similarly, in vivo experimental studies have also shown that infecting mice with T. spiralis could inhibit the growth of ascitic hepatoma H22 [46] and Hepatoma Hep1-6 carcinoma growth [97], as well as slow tumor progression by upregulating the expression of the proapoptotic marker Bcl-2 and improving survival in mice [98].