PIK3CA and bladder transitional cell carcinoma: In our analyzed BLCA cohort, alterations (consensus of pathogenic prediction called “uncertain” or “probably damaging”) in known BLCA-associated genes [1, 58] were identified such as STAG2 (33%), CDKN2A, EP300 and KMT2D (each 25%) an less frequent in KRAS, FAT1, BRAF, ERBB2, KMT2B, ERCC2 and PIK3CA (each 16.7%) (Fig. 1H).