ITK and cancer: In contrast, immune-related kinases (ZAP70 [100], SYK [101], ITK [102], and CSF1R [103]) displayed reduced activity, implicating dampened immune signaling in pathways like PD-L1 Expression and PD-1 Checkpoint in Cancer (hsa05235), T Cell Receptor Signaling (hsa04660), and B Cell Receptor Signaling (WP23) (Fig. 5H).