IL10 and parasitic infectious disease: Although the East Asian and Hispanic cohorts shared few pathways with other ancestries, they both exhibited an enrichment of pathways related to Leishmania parasitic infections and immune responses, including Leishmania phagocytosis, FCGR3A−mediated phagocytosis, Parasite infection and FCGR3A−mediated IL10 synthesis (IGHV4-59, IGKV3D-20, and IGKV1D-33; Fig. 10e and Supplementary Fig. S3).