Other pathways included regulation of gene expression in endocrine-committed (NEUROG3+) progenitor cells (INSM1) in Mixed ancestry and multiple estrogen-related signaling pathways in Southeast Asian ancestry, including Constitutive Signaling by Aberrant PI3K in Cancer (ESR1), extra-nuclear estrogen signaling (ESR1), TFAP2 (AP-2)-mediated transcriptional regulation of growth factors (ESR1), and ESR-mediated signaling (TFF1, ESR1). The gene discussed is ESR1; the disease is cancer.