PRAME and neoplasm: Conversely, GNA11 mutations were associated with Class 2 tumors (p = 0.0005), PRAME(+) status (p = 0.05), increased patient age (p = 0.002), increased tumor diameter (p = 0.004) and tumor thickness (p = 0.002), and they showed a near-significant association with ciliary body involvement (p = 0.06).