Small tumors were more likely than larger tumors to be Class 1 (p < 0.0001), PRAME(−) (p = 0.004), BAP1wt (p = 0.0006), and to lack any BSE mutation (p = 0.001), suggesting that most or all UM begin as small Class 1 tumors that later acquire a BSE mutation during tumor growth. Here, PRAME is linked to neoplasm.