BAP1 and neoplasm: However, in the case of BAP1, mutational inactivation triggers a progressive transcriptomic shift from Class 1 to Class 2 accompanied by a decrease in discriminant score on the Class 1 side of the SVM decision boundary followed by an increase on the Class 2 side that is not tightly linked to CCFBAP1 but likely also depends on alterations that BAP1 loss causes to the tumor immune microenvironment (Fig. 5).