Subsequent KEGG pathway enrichment analysis of these DEGs revealed significant enrichment in the following pathways: TGF-β signaling pathway, PI3K-Akt signaling pathway, Hippo signaling pathway, MAPK signaling pathway, TNF signaling pathway, JAK-STAT signaling pathway, Proteoglycans in cancer, MicroRNAs in cancer, Pathways related to tumorigenesis, Cellular senescence (Fig. 2B). The gene discussed is TNF; the disease is cancer.