To elucidate the functional impact of CMTM6 on WWP2-mediated regulation in HCC, we generated two novel stable HuH-7 cell models: dual-knockdown (sh-WWP2-1+sh-CMTM6-1) and co-overexpression (WWP2-oe+CMTM6-oe) cell lines. This evidence concerns the gene WWP2 and hepatocellular carcinoma.