Our data revealed that HMC alone markedly attenuated skin erythema, scaling, epidermal hyperplasia, body weight loss, and histopathological alterations, while significantly (P < 0.001) suppressed splenomegaly and oxidative stress, and reduced the elevated levels of interleukin (IL)-23, IL-17A, and cyclooxygenase-2, as well as downregulated the expression of tumor necrosis factor-α. This evidence concerns the gene TNF and Splenomegaly.