In two studies, Trp53 was found to attenuate cancer cell migration and invasion through repressing the chemokine SDF-1 and its cognate receptor CXCR413,38 In addition, TSPAN12, a p53-regulated gene, was found to be required to enhance cancer invasiveness and proliferation elicited by p53 downregulated fibroblasts39. The gene discussed is CXCL12; the disease is cancer.