As shown in Fig. 4e, we observed that expression of SAA1 and SAA2 is significantly higher in breast cancer samples with mutant TP53 compared to those with WT TP53. Although it remains unclear whether here SAA1 and SAA2 are expressed by stromal or tumor cells—a question best addressed by spatial or single-cell sequencing—these findings further imply the association between mutant p53 and secretory factor expression. Here, TP53 is linked to breast cancer.