Moreover, treatment of tumor-bearing mice with oral Nampt inhibitor OT-82 (20 mg/kg orally, once daily for three consecutive days followed by four days of rest, repeated for two weeks) resulted in a similar repolarization of neutrophils, characterized by reduced accumulation of dysfunctional, tissue-toxic neutrophil subsets in lungs (Fig. S19c). This evidence concerns the gene NAMPT and neoplasm.