CSF3 and Decreased total neutrophil count: Neutralizing anti-G-CSFR antibodies were shown to block G-CSF-induced neutrophilia, without inducing neutropenia, in non-human primates.38 Moreover, anti-G-CSFR antibodies reduced neutrophilic inflammation during pneumococcal or influenza respiratory infections, without compromising bacterial clearance39 and increased neutrophil CD62L expression, reverting them to an active antibacterial phenotype.40