DNER and cancer: To further investigate this finding, we compiled a list of genes consistently up- and down-regulated by HDAC inhibitors across various cancers using the Library of Integrated Network-based Cellular Signature (iLINCS) [41] database, and found that most of these genes were not only up- and down-regulated by HDAC inhibitor treatments in UM cells, but also following BET inhibition with mivebresib (Fig. 4F; Supplementary Fig. 4E, F).