TLR4 and myocardial infarction: We hypothesise that the combined effect of myocardial infarction and high‐fat diet (HFD) feeding exacerbates cardiac inflammation, oxidative stress and fibrotic remodelling through dysregulation of nitric oxide synthase isoforms, upregulation of proinflammatory cytokines and altered activation of key signalling pathways including NFκB and TLR4.