Although lactate oxidase (LOx) can degrade lactate,its oxidation product, pyruvate, may inadvertently fuel tumor growth.To overcome this limitation, we engineered dual-processor ACs coencapsulatingLOx and pyruvate decarboxylase (PDC), enabling selective conversionof lactate into cytotoxic acetaldehyde while suppressing pyruvateand hydrogen peroxide accumulation. The gene discussed is PDC; the disease is neoplasm.