MT3 and Alzheimer disease: Previous studies have shown that in Mt3 KO mice, lysosomal dysfunction and disrupted actin dynamics exacerbate neurodegeneration triggered by toxic Aβ protein.[7] Based on this, we investigated whether Mt3 activation in the brain via CRISPRa lipid nanocomplexes could reduce Aβ levels and mitigate memory impairments in an AD mouse model.