Endogenous fructose production occurs in other tissues such as the liver [58], and the impact of UA‐polyol pathway interplay on liver disease and endothelial damage is well documented [21, 40, 41, 59, 60], and both UA and the polyol pathway are known to mediate activation of the NLRP3 inflammasome [61, 62]. This evidence concerns the gene NLRP3 and liver disorder.