Intraspinally injected FeNCs-TRPV1 induced TRPV1 desensitization in rats exposed to repetitive and transient ACMF before ischemia, resulting in the inhibition of TRPV1-mediated Ca<sup>2+</sup> signaling and neuropeptide release in the spinal cord during myocardial ischemia and reperfusion. Here, TRPV1 is linked to ischemia.