A study on the Dutch population showed, including the PRS313 in family history-based risk prediction, may change screening recommendations in up to 34 % of individuals from families with no pathogenic variants in any of the five breast cancer genes (BRCA1, BRCA1, PALB2, CHEK2, or ATM) modeled in BOADICEA.28 This evidence concerns the gene PALB2 and breast carcinoma.