These findings underscore WNT10A’s role in Wnt/β-catenin signaling, driving proliferation, EMT, and metastasis, thereby linking chronic inflammation and viral infection to hepatocarcinogenesis.39, 40 Our results align with prior gene expression profiling showing WNT10A upregulation in PBMCs of HCV-related HCC patients41, and a transcriptomic study showed that WNT10A remained epigenetically upregulated in HCV-infected liver tissue even after DAA-mediated viral clearance.24 This evidence concerns the gene WNT10A and hepatocellular carcinoma.