The elevated expression of WNT10A (7.11-fold) in PBMCs of patients with chronic HCV infection remained high in HCV-induced HCC cases, independent of antiviral treatment (2.04-fold in the DAAs cured HCV-HCC group, 2.17-fold in the SVR group, and 2.69-fold in the non-treated HCV-HCC group). This evidence concerns the gene WNT10A and hepatocellular carcinoma.