LGI1 and Seizure: It also functions to modulate the neuronal excitability through the voltage-gated potassium Kv1.1 channels, and the postsynaptic ADAM22, which interacts with AMPA receptors.72, 73 The alteration of LGI1 functions can be seen in autosomal dominant temporal lobe epilepsy (ADLTE) and autoimmune limbic encephalitis, both characterized by epileptic seizures.74