CDK2 and epilepsy: It is widely distributed throughout the CNS, indicating its physiologic importance.58, 59 Studies have highlighted the pathophysiologic role of AMPA receptors in epilepsy.60, 61 Besides, AMPA-receptor antagonists have been found effective in reducing the severity of seizures and inhibiting the chemically induced seizures.62, 63, 64 The protein human cyclin dependent kinase 2 (PDB ID: 1pxo) was selected as it is involved indirectly in the epilepsy mechanism.