CLIC2 expression in human HNSCC was examined histopathologically.<h4>Results</h4>Forced expression of CLIC2 in HNSCC cells was accompanied by increased cell proliferation, resistance against natural killer cells, and expression of tumor-promoting genes in addition to increased tumorigenicity upon xenografting in a mouse model. The gene discussed is CLIC2; the disease is head and neck squamous cell carcinoma.