This Hsp70-Bim protein-protein interaction (PPI) is enriched in tyrosine-kinase-inhibitor (TKI)-resistant chronic myeloid leukemia, endocrine-refractory breast cancer, glioblastoma, and other "chaperone-addicted" tumors, making it a selective vulnerability rather than a housekeeping liability. Here, BCL2L11 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.