CGAS and neurodegenerative disease: As with other neurodegenerative disease–associated protein aggregates, α Syn fibrils can elicit cGAS/STING assembly.α Syn-PFF–injected mice upregulated γH2AX (an indicator of nuclear dsDNA damage), cGAS, STING, and pTBK1 as well as STING-dependent IFNβ levels (117).