CPSF6 and infection: If transcriptional rewiring triggered by CPSF6 recruitment to capsid cores enhances CD4 + T cell permissivity to infection, we would expect that mutations that prevent CPSF6 binding would decrease infectivity, as has been reported with the N74D capsid mutant virus [22,23], and that knock-out of CPSF6 would help rescue infection of those viruses.