Exposing Day 1 tcer-1;lipl-1 adults to 60μg Cer 24 for 24 h before, and during, PA14 infection enhanced their survival substantially as compared to control animals exposed to solvent alone (Fig 5J and S7 Table) indicating a physiological relevance to the LIPL-1-mediated production of this species. Here, LIPJ is linked to infection.